Chronic administration of antipsychotics impede behavioral recovery after experimental traumatic brain injury

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Chronic administration of antipsychotics impede behavioral recovery after experimental traumatic brain injury.

Antipsychotics are often administered to traumatic brain injured (TBI) patients as a means of controlling agitation, albeit the rehabilitative consequences of this intervention are not well known. Hence, the goal of this study was to evaluate the effects of risperidone (RISP) and haloperidol (HAL) on behavioral outcome after experimental TBI. Anesthetized rats received either a cortical impact ...

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Identification of Imaging and Clinical Markers Predicting Chronic Sleep Disturbances After Traumatic Brain Injury in Adults

Background and Aim: We aimed to determine the prognostic imaging and clinical markers of chronic Post-Traumatic Sleep-Wake Disorders (PTSWDs) with a special focus on the early cognitive and executive dysfunctions following Traumatic Brain Injury (TBI). The prevalence rate of Post-Traumatic Psychiatric Disorders (PTPDs) in various sleep disorders was also investigated. Methods and Materials/Pat...

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ژورنال

عنوان ژورنال: Neuroscience Letters

سال: 2008

ISSN: 0304-3940

DOI: 10.1016/j.neulet.2008.10.076